Blood–brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung–brain microphysiological system

P Wang, L Jin, M Zhang, Y Wu, Z Duan, Y Guo… - Nature Biomedical …, 2023 - nature.com
In some patients, COVID-19 can trigger neurological symptoms with unclear pathogenesis.
Here we describe a microphysiological system integrating alveolus and blood–brain barrier …

Pathophysiologic mechanisms of cerebral endotheliopathy and stroke due to Sars-CoV-2

V Kakarla, N Kaneko, M Nour… - Journal of Cerebral …, 2021 - journals.sagepub.com
Cerebrovascular events have emerged as a central feature of the clinical syndrome
associated with Sars-CoV-2 infection. This increase in infection-related strokes is marked by …

The neurobiology of SARS-CoV-2 infection

J Meinhardt, S Streit, C Dittmayer, RV Manitius… - Nature Reviews …, 2024 - nature.com
Worldwide, over 694 million people have been infected with SARS-CoV-2, with an estimated
55–60% of those infected developing COVID-19. Since the beginning of the pandemic in …

A peek into Pandora's box: COVID-19 and neurodegeneration

A Chandra, A Johri - Brain Sciences, 2022 - mdpi.com
Ever since it was first reported in Wuhan, China, the coronavirus-induced disease of 2019
(COVID-19) has become an enigma of sorts with ever expanding reports of direct and …

Infection of brain pericytes underlying neuropathology of COVID-19 patients

M Bocci, C Oudenaarden, X Sàenz-Sardà… - International journal of …, 2021 - mdpi.com
A wide range of neurological manifestations have been associated with the development of
COVID-19 following SARS-CoV-2 infection. However, the etiology of the neurological …

COVID-19, neuropathology, and aging: SARS-CoV-2 neurological infection, mechanism, and associated complications

RS Kalra, JK Dhanjal, AS Meena, VC Kalel… - Frontiers in Aging …, 2021 - frontiersin.org
The spectrum of health complications instigated by coronavirus disease 2019 (COVID-19,
caused by the novel severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2) …

COVID-19 and cognitive impairment: neuroinvasive and blood‒brain barrier dysfunction

Y Chen, W Yang, F Chen, L Cui - Journal of Neuroinflammation, 2022 - Springer
Abstract Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), has led to a global pandemic. Although COVID-19 …

SARS-CoV-2 infects neurons and induces neuroinflammation in a non-human primate model of COVID-19

D Beckman, A Bonillas, GB Diniz, S Ott, JW Roh… - Cell reports, 2022 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of
coronavirus disease 2019 (COVID-19), can induce a plethora of neurological complications …

SARS-CoV-2: is there neuroinvasion?

C McQuaid, M Brady, R Deane - Fluids and Barriers of the CNS, 2021 - Springer
Abstract Background SARS-CoV-2, a coronavirus (CoV), is known to cause acute respiratory
distress syndrome, and a number of non-respiratory complications, particularly in older male …

Shared inflammatory pathology of stroke and COVID-19

KE Sánchez, GA Rosenberg - International Journal of Molecular Sciences, 2022 - mdpi.com
Though COVID-19 is primarily characterized by symptoms in the periphery, it can also affect
the central nervous system (CNS). This has been established by the association between …