Lens development is a stepwise process accompanied by the sequential activation of
transcription factors. Transcription factor genes can be classified into three groups according …

Lens-cell differentiation occurs at a fairly early stage of embryogenesis and results in very
simple tissue architecture. These features allow the embryonic lens to provide a paradigm of …

Since the pioneering work of the early 1900s, the lens has been used as a model system for
the study of tissue development in vertebrates. A number of embryological transplantation …

The lens was the first tissue in which the concept of embryonic induction was demonstrated.
For many years lens induction was thought to occur at the time the optic vesicle and lens …

Recent studies demonstrated a number of links between chromatin structure, gene
expression, extracellular signaling and cellular differentiation during lens development …

The ocular lens is a model system for understanding important aspects of embryonic
development, such as cell specification and the spatiotemporally controlled formation of a …

Cell determination in vertebrates requires integration of many events, although the
mechanisms controlling the different stages in this process are poorly understood. While …

Embryologists at the turn of the century discovered the process of embryonic induction while
investigating the mechanisms of lens determination. The simple view of lens induction from …

This review provides an overview of our current understanding of signaling mechanisms
involved in lens induction, which are presented in context of the major stages of lens …

For more than a century, the lens has provided a relatively simple structure in which to study
developmental mechanisms. Lens induction, where adjacent tissues signal the cell fate …