[HTML][HTML] SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

EA Albornoz, AA Amarilla, N Modhiran, S Parker… - Molecular …, 2023 - nature.com
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …

[HTML][HTML] Complications of COVID-19 on the Central Nervous System: Mechanisms and Potential Treatment for Easing Long COVID

ZYD Wei, K Liang, AK Shetty - Aging and Disease, 2023 - ncbi.nlm.nih.gov
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades human cells by
binding to the angiotensin-converting-enzyme-2 (ACE-2) using a spike protein and leads to …

Molecular docking of SARS-COV-2 Spike epitope sequences identifies heterodimeric peptide-protein complex formation with human Zo-1, TLR8 and brain specific …

S Dasgupta, M Bandyopadhyay - Medical hypotheses, 2021 - Elsevier
SARS-COV-2 infection causes severe respiratory tract illness leading to asphyxia and death.
The onset of infection is associated with loss of smell, blurred vision, headache with …

[HTML][HTML] Emerging role of kinin B1 receptor in persistent neuroinflammation and neuropsychiatric symptoms in mice following recovery from SARS-CoV-2 infection

S Sriramula, D Theobald, RU Parekh, SM Akula… - Cells, 2023 - mdpi.com
Evidence suggests that patients with long COVID can experience neuropsychiatric,
neurologic, and cognitive symptoms. However, these clinical data are mostly associational …

[HTML][HTML] SARS-CoV-2 Spike protein S2 subunit modulates γ-secretase and enhances amyloid-β production in COVID-19 neuropathy

G Ma, DF Zhang, QC Zou, X Xie, L Xu, XL Feng, X Li… - Cell Discovery, 2022 - nature.com
Dear Editor, SARS-CoV-2-induced multi-lineage neural cell dysregulation has been
documented 1. SARS-CoV-2 infection elevates neuroinflammation 2, alters brain structure 3 …

[HTML][HTML] Microglial Inflammatory Responses to SARS‐CoV‐2 Infection: A Comprehensive Review

R Dey, B Bishayi - Cellular and Molecular Neurobiology, 2024 - Springer
Abstract Coronavirus disease 2019 (COVID-19) is primarily a respiratory disease causing a
worldwide pandemic in the year of 2019. SARS‐CoV‐2 is an enveloped, positive-stranded …

[HTML][HTML] SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein

R Khaddaj-Mallat, N Aldib, M Bernard… - Neurobiology of …, 2021 - Elsevier
Abstract Coronavirus disease 19 (COVID-19) is a respiratory illness caused by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 pathogenesis causes …

Blood-brain barrier function in response to SARS-CoV-2 and its spike protein

Ł Suprewicz, K Fiedoruk… - Neurologia i …, 2023 - journals.viamedica.pl
The typical manifestation of coronavirus 2 (CoV-2) infection is a severe acute respiratory
syndrome (SARS) accompanied by pneumonia (COVID-19). However, SARS-CoV-2 can …

SARS-CoV-2 mediated neurological disorders in COVID-19: Measuring the pathophysiology and immune response

PC Hsu, M Shahed-Al-Mahmud - Life sciences, 2022 - Elsevier
The emergence of beta-coronavirus SARS-CoV-2 gets entry into its host cells by recognizing
angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 …

[HTML][HTML] Elucidating the neuropathologic mechanisms of SARS-CoV-2 infection

M Pacheco-Herrero, LO Soto-Rojas… - Frontiers in …, 2021 - frontiersin.org
The current pandemic caused by the new severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) has become a public health emergency. To date, March 1, 2021, coronavirus …