Background Cisplatin is widely used for chemotherapy of head and neck squamous cell
carcinoma. However, details of the molecular mechanism responsible for cisplatin …

Resistance to cisplatin is a major obstacle to successful treatment of head and neck
squamous cell carcinoma (HNSCC). To investigate the molecular mechanism of this …

Cisplatin (CDDP) is widely used for chemotherapy of many malignancies, especially of oral
squamous cell carcinoma (SCC). However, because the mechanism of resistance to CDDP …

Cisplatin and carboplatin are among the most active and widely used cytotoxic anticancer
drugs. However, the acquisition or presence of resistance significantly undermines the …

Cisplatin (CDDP) is a widely used potent chemotherapeutic agent for many malignancies.
However, the mechanism of resistance to CDDP remains unclear. To investigate the …

Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate
and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which …

The efficacy of cisplatin during cancer chemotherapy is often impaired by the emergence of
cancer cells which become resistant to chemotherapeutic agents. While various …

We aimed to investigate the mechanisms of cisplatin resistance using an in vitro cancer
model. A derivative breast cancer cell line (MCF-7 CR) was established which demonstrated …

Cisplatin-based chemotherapeutic regimens are frequently used for treatments of solid
tumors. However, tumor cells may have inherent or acquired cisplatin resistance, and the …

Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor
cells can acquire resistance to the damage caused by cisplatin, generating genetic and …