Midlife systemic inflammation is associated with frailty in later life: the ARIC study

KA Walker, J Walston, RF Gottesman… - The Journals of …, 2019 - academic.oup.com
Background Evidence suggests that systemic inflammation may have a mechanistic role in
age-related frailty, yet prospective data is limited. We examined whether systemic …

Long-term assessment of inflammation and healthy aging in late life: the Cardiovascular Health Study All Stars

NS Jenny, B French, AM Arnold… - … Series A: Biomedical …, 2012 - academic.oup.com
Background. Associations of inflammation with age-related pathologies are documented;
however, it is not understood how changes in inflammation over time impact healthy aging …

[HTML][HTML] Inflammation and frailty in the elderly: a systematic review and meta-analysis

P Soysal, B Stubbs, P Lucato, C Luchini, M Solmi… - Ageing research …, 2016 - Elsevier
The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …

Cross-sectional and longitudinal relationships between inflammatory biomarkers and frailty in community-dwelling older men: the concord health and ageing in men …

B Hsu, V Hirani, RG Cumming… - The Journals of …, 2019 - academic.oup.com
Background Previous studies demonstrated associations between IL-6 and frailty, but
associations between a wide range of cytokines, chemokines, and growth factors with …

[HTML][HTML] C-reactive protein and white blood cell are associated with frailty progression: a longitudinal study

Z Cheng, D He, J Li, Q Wu, Z Liu, Y Zhu - Immunity & Ageing, 2022 - Springer
Background Systemic inflammation has been linked to diseases and frailty. However, little is
known about the effect of systemic inflammation on frailty progression with a longitudinal …

Inflammatory biomarkers in older adults with frailty: a systematic review and meta-analysis of cross-sectional studies

YS Xu, MM Wang, D Chen, X Jiang… - Aging clinical and …, 2022 - Springer
Background Systemic chronic inflammation has been proposed as an essential mediating
factor in frailty, and several studies tested its relationship with frailty. However, the issue is …

Association between inflammatory-related disease burden and frailty: results from the Women's Health and Aging Studies (WHAS) I and II

SS Chang, CO Weiss, QL Xue, LP Fried - Archives of gerontology and …, 2012 - Elsevier
Frailty is associated with a pro-inflammatory state, which has been characterized by
elevated levels of systemic inflammatory biomarkers, but has not been related to the number …

Inflammatory marker trajectories associated with frailty and ageing in a 20‐year longitudinal study

LD Samson, AM Buisman, JA Ferreira… - Clinical & …, 2022 - Wiley Online Library
Objective The aim of this exploratory study was to investigate the development of low‐grade
inflammation during ageing and its relationship with frailty. Methods The trajectories of 18 …

[HTML][HTML] Frailty has a stronger association with inflammation than age in older veterans

P Van Epps, D Oswald, PA Higgins, TR Hornick… - Immunity & …, 2016 - Springer
Background Upregulation of pro-inflammatory cytokines has not only been associated with
increased morbidity and mortality in older adults but also has been linked to frailty. In the …

Association of 10-year C-reactive protein trajectories with markers of healthy aging: findings from the English longitudinal study of aging

C Lassale, GD Batty, A Steptoe, D Cadar… - The Journals of …, 2019 - academic.oup.com
Background Elevated systematic inflammation is a hallmark of aging, but the association of
long-term inflammation trajectories with subsequent aging phenotypes has been little …