Background Evidence suggests that systemic inflammation may have a mechanistic role in
age-related frailty, yet prospective data is limited. We examined whether systemic …

Background. Associations of inflammation with age-related pathologies are documented;
however, it is not understood how changes in inflammation over time impact healthy aging …

The pathogenesis of frailty and the role of inflammation is poorly understood. We examined
the evidence considering the relationship between inflammation and frailty through a …

Background Previous studies demonstrated associations between IL-6 and frailty, but
associations between a wide range of cytokines, chemokines, and growth factors with …

Background Systemic inflammation has been linked to diseases and frailty. However, little is
known about the effect of systemic inflammation on frailty progression with a longitudinal …

Background Systemic chronic inflammation has been proposed as an essential mediating
factor in frailty, and several studies tested its relationship with frailty. However, the issue is …

Frailty is associated with a pro-inflammatory state, which has been characterized by
elevated levels of systemic inflammatory biomarkers, but has not been related to the number …

Objective The aim of this exploratory study was to investigate the development of low‐grade
inflammation during ageing and its relationship with frailty. Methods The trajectories of 18 …

Background Upregulation of pro-inflammatory cytokines has not only been associated with
increased morbidity and mortality in older adults but also has been linked to frailty. In the …

Background Elevated systematic inflammation is a hallmark of aging, but the association of
long-term inflammation trajectories with subsequent aging phenotypes has been little …