Recent studies demonstrated a number of links between chromatin structure, gene
expression, extracellular signaling and cellular differentiation during lens development …

Ocular lens development represents an advantageous system in which to study regulatory
mechanisms governing cell fate decisions, extracellular signaling, cell and tissue …

Lens-cell differentiation occurs at a fairly early stage of embryogenesis and results in very
simple tissue architecture. These features allow the embryonic lens to provide a paradigm of …

Since the pioneering work of the early 1900s, the lens has been used as a model system for
the study of tissue development in vertebrates. A number of embryological transplantation …

Over the past several decades, the biology of the developing lens has been investigated
using molecular genetics-based approaches in various vertebrate model systems. These …

The eye and lens represent excellent models to understand embryonic development at
cellular and molecular levels. Initial 3D formation of the eye depends on a reciprocal …

This review gives a brief account of the main processes of lens development, including
induction, morphogenesis, differentiation and growth. It describes what is known about the …

Lens development is a stepwise process accompanied by the sequential activation of
transcription factors. Transcription factor genes can be classified into three groups according …

The lens was the first tissue in which the concept of embryonic induction was demonstrated.
For many years lens induction was thought to occur at the time the optic vesicle and lens …

Background Promoters and enhancers are cis-regulatory DNA sequences that control
specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that …