Famotidine inhibits toll-like receptor 3-mediated inflammatory signaling in SARS-CoV-2 infection

R Mukherjee, A Bhattacharya, D Bojkova… - Journal of Biological …, 2021 - ASBMB
Apart from prevention using vaccinations, the management options for COVID-19 remain
limited. In retrospective cohort studies, use of famotidine, a specific oral H2 receptor …

COVID-19: famotidine, histamine, mast cells, and mechanisms

RW Malone, P Tisdall, P Fremont-Smith, Y Liu… - Frontiers in …, 2021 - frontiersin.org
SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19
differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not …

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm

H Yang, SJ George, DA Thompson, HA Silverman… - Molecular …, 2022 - Springer
Background Severe COVID-19 is characterized by pro-inflammatory cytokine release
syndrome (cytokine storm) which causes high morbidity and mortality. Recent observational …

Histamine receptors and COVID-19

M Ennis, K Tiligada - Inflammation Research, 2021 - Springer
Objective Reports that the over-the-counter histamine H 2 receptor antagonist famotidine
could help treat the novel coronavirus disease (COVID-19) appeared from April 2020. We …

Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

C Mura, S Preissner, S Nahles, M Heiland… - … and Targeted Therapy, 2021 - nature.com
The COVID-19 pandemic has driven great interest in the therapeutic potential of repurposed
drugs with well-established benefits and safety profiles (toxicity, bioavailability, etc.), many of …

The in-vitro effect of famotidine on sars-cov-2 proteases and virus replication

M Loffredo, H Lucero, DY Chen, A O'Connell… - Scientific reports, 2021 - nature.com
The lack of coronavirus-specific antiviral drugs has instigated multiple drug repurposing
studies to redirect previously approved medicines for the treatment of SARS-CoV-2, the …

[HTML][HTML] Histamine potentiates SARS-CoV-2 spike protein entry into endothelial cells

S Raghavan, MD Leo - Frontiers in Pharmacology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus
disease (COVID-19) is one of the most serious global health crises in recent history. COVID …

Effect of famotidine on hospitalized patients with COVID-19: A systematic review and meta-analysis

L Chiu, M Shen, CH Lo, N Chiu, A Chen, HJ Shin… - PLoS …, 2021 - journals.plos.org
Introduction Famotidine is a competitive histamine H2-receptor antagonist most commonly
used for gastric acid suppression but thought to have potential efficacy in treating patients …

Does famotidine reduce the risk of progression to severe disease, death, and intubation for COVID-19 patients? A systemic review and meta-analysis

C Sun, Y Chen, L Hu, Y Wu, M Liang… - Digestive diseases and …, 2021 - Springer
Background Famotidine was reported to potentially provide benefits to Coronavirus Disease
2019 (COVID-19) patients. However, it remains controversial whether it is effective in …

Famotidine against SARS-CoV2: a hope or hype?

R Ghosh, S Chatterjee, S Dubey… - Mayo Clinic …, 2020 - mayoclinicproceedings.org
To the Editor: Coronavirus disease 2019 (COVID-19) is globe-trotting, and thousands of
researchers and stakeholders are spending reposeless days and sleepless nights in search …