Background Global but predictable changes impact the DNA methylome as we age, acting
as a type of molecular clock. This clock can be hastened by conditions that decrease …

Background Age-associated epigenetic changes are implicated in aging. Notably, age-
associated DNA methylation changes comprise a so-called aging “clock”, a robust …

Background DNA methylation changes at a discrete set of sites in the human genome are
predictive of chronological and biological age. However, it is not known whether these …

Aging, often considered a result of random cellular damage, can be accurately estimated
using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we …

Background Mammalian species exhibit a wide range of lifespans. To date, a robust and
dynamic molecular readout of these lifespan differences has not yet been identified. Recent …

The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure
subject age. These clocks are acknowledged as a highly accurate molecular correlate of …

Aging is characterized by numerous molecular changes, such as accumulation of molecular
damage and altered gene expression, many of which are linked to DNA methylation. Here …

The DNA methylation levels of certain CpG sites are thought to reflect the pace of human
aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG …

Aging is often perceived as a degenerative process resulting from random accrual of cellular
damage over time. Despite this, age can be accurately estimated by epigenetic clocks based …