Accelerated Epigenetic Aging Is Associated With Multiple Cardiometabolic, Hematologic, and Renal Abnormalities: A Project Baseline Health Substudy
B Uchehara, L Coulter Kwee, J Regan… - Circulation: Genomic …, 2023 - Am Heart Assoc
Background: Epigenetic clocks estimate chronologic age using methylation levels at specific
loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal …
loci. We tested the hypothesis that accelerated epigenetic aging is associated with abnormal …
The association of accelerated epigenetic age with all-cause mortality in cardiac catheterization patients as mediated by vascular and cardiometabolic outcomes
Background Epigenetic age is a DNA methylation-based biomarker of aging that is accurate
across the lifespan and a range of cell types. The difference between epigenetic age and …
across the lifespan and a range of cell types. The difference between epigenetic age and …
Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging
Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …
on patterns of DNA methylation—can be computed and is associated with an array of factors …
Prospective study of epigenetic age acceleration and incidence of cardiovascular disease outcomes in the ARIC study (Atherosclerosis Risk in Communities)
NS Roetker, JS Pankow, J Bressler… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: DNA methylation-based patterns of biological aging, known as epigenetic age
acceleration, are predictive of all-cause mortality, but little is known about their association …
acceleration, are predictive of all-cause mortality, but little is known about their association …
Epigenetic clocks and incident heart failure: The Atherosclerosis Risk in Communities (ARIC)
S Nguyen, CA Northuis, W Guan, J Bressler, M Grove… - Circulation, 2021 - Am Heart Assoc
Background: DNA methylation (DNAm)-based measures of aging, termed epigenetic clocks
(EC), are associated with aging-related outcomes including cardiovascular disease (CVD) …
(EC), are associated with aging-related outcomes including cardiovascular disease (CVD) …
Epigenetic age acceleration is associated with blood lipid levels in a multi-ancestry sample of older US adults
Background Dyslipidemia, which is characterized by an unfavorable lipid profile, is a key risk
factor for cardiovascular disease (CVD). Understanding the relationships between …
factor for cardiovascular disease (CVD). Understanding the relationships between …
Association of cardiovascular health and epigenetic age acceleration
Background Cardiovascular health (CVH) has been defined by the American Heart
Association (AHA) as the presence of the “Life's Simple 7” ideal lifestyle and clinical factors …
Association (AHA) as the presence of the “Life's Simple 7” ideal lifestyle and clinical factors …
Intrinsic and extrinsic epigenetic age acceleration are associated with hypertensive target organ damage in older African Americans
JA Smith, J Raisky, SM Ratliff, J Liu, SLR Kardia… - BMC medical …, 2019 - Springer
Background Epigenetic age acceleration, a measure of biological aging based on DNA
methylation, is associated with cardiovascular mortality. However, little is known about its …
methylation, is associated with cardiovascular mortality. However, little is known about its …
Epigenetic age acceleration: a biological doomsday clock for cardiovascular disease?
MM Mendelson - Circulation: Genomic and Precision Medicine, 2018 - Am Heart Assoc
2 Circ Genom Precis Med. 2018; 11: e002089. DOI: 10.1161/CIRCGEN. 118.002089 March
2018 age predictors were moderately correlated with each other (r= 0.6), and there was a …
2018 age predictors were moderately correlated with each other (r= 0.6), and there was a …
Cardiovascular correlates of epigenetic aging across the adult lifespan: a population-based study
D Liu, NA Aziz, G Pehlivan, MMB Breteler - GeroScience, 2023 - Springer
Individuals with a similar chronological age can exhibit marked differences in cardiovascular
risk profiles, but it is unknown whether this variation is related to different rates of biological …
risk profiles, but it is unknown whether this variation is related to different rates of biological …