Widespread sex dimorphism in aging and age-related diseases

NK Sampathkumar, JI Bravo, Y Chen, PS Danthi… - Human genetics, 2020 - Springer
Although aging is a conserved phenomenon across evolutionary distant species, aspects of
the aging process have been found to differ between males and females of the same …

Sex differences in biological aging with a focus on human studies

S Hägg, J Jylhävä - Elife, 2021 - elifesciences.org
Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

Sex differences in aging: genomic instability

KE Fischer, NC Riddle - The Journals of Gerontology: Series A, 2018 - academic.oup.com
Aging is characterized by decreasing physiological integration, reduced function, loss of
resilience, and increased risk of death. Paradoxically, although women live longer, they …

Sex gap in aging and longevity: can sex chromosomes play a role?

GAB Marais, JM Gaillard, C Vieira, I Plotton… - Biology of sex …, 2018 - Springer
It is well known that women live longer than men. This gap is observed in most human
populations and can even reach 10–15 years. In addition, most of the known super …

Sex differences in longevity and in responses to anti-aging interventions: a mini-review

SN Austad, A Bartke - Gerontology, 2015 - karger.com
A robust, often underappreciated, feature of human biology is that women live longer than
men not just in technologically advanced, low-mortality countries such as those in Europe or …

Evolution of sex differences in lifespan and aging: causes and constraints

AA Maklakov, V Lummaa - BioEssays, 2013 - Wiley Online Library
Why do the two sexes have different lifespans and rates of aging? Two hypotheses based
on asymmetric inheritance of sex chromosomes (“unguarded X”) or mitochondrial genomes …

Sex differences in longevity and aging

SN Austad - Handbook of the Biology of Aging, 2011 - Elsevier
Publisher Summary This chapter reviews the copious evidence for the robustness of
women's survival advantage, discusses some of the extant evolutionary and mechanistic …

Sex differences in genetic associations with longevity

Y Zeng, C Nie, J Min, H Chen, X Liu, R Ye… - JAMA network …, 2018 - jamanetwork.com
Importance Sex differences in genetic associations with human longevity remain largely
unknown; investigations on this topic are important for individualized health care. Objective …

Sex‐specific aging in animals: perspective and future directions

AM Bronikowski, RP Meisel, PR Biga, JR Walters… - Aging …, 2022 - Wiley Online Library
Sex differences in aging occur in many animal species, and they include sex differences in
lifespan, in the onset and progression of age‐associated decline, and in physiological and …

Sex differences in lifespan

SN Austad, KE Fischer - Cell metabolism, 2016 - cell.com
Sex differences in longevity can provide insights into novel mechanisms of aging, yet they
have been little studied. Surprisingly, sex-specific longevity patterns are best known in wild …