Few experiences in the work of a neurologic diagnostician are more disquieting than
informing both patient and family that the diagnosis is Alzheimer's disease (AD). Yet, with the …

BACKGROUND: Alzheimer's disease (AD) is a common fatal neurodegenerative disorder for
which there is no effective treatment or cure. The biological basis of AD is poorly understood …

Alzheimer's disease is the most common neurodegenerative disorder of aging, accounting
for an estimated two-thirds of all cases of senile dementia. Epidemiologic studies have failed …

Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common
type of dementia, occurring in mid to late life. The neuropathological hallmarks of this …

Like several other adult onset neurodegenerative diseases, Alzheimer's disease is a
multifactorial illness with both genetic and non-genetic causes. Recent genetic studies have …

Approximately half of the Alzheimer's disease (AD) cases that are associated with early
onset appear to be transmitted as a pure genetic, autosomal dominant trait. Genetic …

In recent years, important progress has been made in uncovering genes implicated in
Alzheimer's disease (AD). Three causal genes have been identified in which mutations …

Four genes involved in the development of Alzheimer disease have been identified. Three
fully penetrant (deterministic) genes lead to the development of Alzheimer disease in …

Application of genetic paradigms to Alzheimer's disease (AD) has led to confirmation that
genetic factors play a role in this disease. Additionally, researchers now understand that AD …

Mutations in the genes encoding the presenilins cause the majority of early-onset cases of
Alzheimer's disease (AD). The identification of the presenilin genes has provided new …