Cytokine production after influenza vaccination in a healthy elderly population

ED Bernstein, EM Gardner, E Abrutyn, P Gross… - Vaccine, 1998 - Elsevier
Influenza vaccination is less efficacious in the elderly than in the young. To characterize this
age-related decrease in immune response to influenza vaccination, antibody and cell …

Immune response to influenza vaccination in a large healthy elderly population

E Bernstein, D Kaye, E Abrutyn, P Gross, M Dorfman… - Vaccine, 1999 - Elsevier
Elderly individuals not only demonstrate a greater risk of morbidity and mortality from
influenza than the young, but also have greater difficulty mounting a protective response to …

Role of humoral and cell-mediated immunity in protection from influenza disease after immunization of healthy elderly

DM Murasko, ED Bernstein, EM Gardner, P Gross… - Experimental …, 2002 - Elsevier
While influenza immunization significantly reduces the risk of pneumonia and associated
deaths, vaccination of elderly only affords 30–50% protection against influenza disease. The …

Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals

JJ Goronzy, JW Fulbright, CS Crowson… - Journal of …, 2001 - Am Soc Microbiol
Elderly individuals are at high risk for morbidity and mortality when infected with influenza
virus. Vaccinations with inactivated virus are less effective in the elderly due to the declining …

Immune response to influenza vaccination in institutionalized elderly: effect on different T-cell subsets

JE McElhaney, S Gravenstein, CM Upshaw, JW Hooton… - Vaccine, 1998 - Elsevier
Humoral and cellular immunological responses to influenza vaccination were measured in
volunteers in a long-term care facility. All participants were vaccinated with the commercially …

The effect of influenza vaccination on IL2 production in healthy elderly: implications for current vaccination practices

JE McElhaney, GS Meneilly, BL Beattie… - Journal of …, 1992 - academic.oup.com
Age-related senescence of T-cell mediated responses is well recognized. This study was
designed to determine how aging affects the T-cell mediated Interleukin 2 (IL2) response to …

[HTML][HTML] Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies

S Sasaki, M Sullivan, CF Narvaez… - The Journal of …, 2011 - Am Soc Clin Investig
During seasonal influenza epidemics, disease burden is shouldered predominantly by the
very young and the elderly. Elderly individuals are particularly affected, in part because …

[HTML][HTML] Influenza vaccine-induced antibody responses are not impaired by frailty in the community-dwelling elderly with natural influenza exposure

V Narang, Y Lu, C Tan, XFN Camous… - Frontiers in …, 2018 - frontiersin.org
Background: Elderly adults over 65 years of age are recommended to receive seasonal
influenza vaccination as they are at a higher risk of infection and its complications than the …

High interleukin-10 production is associated with low antibody response to influenza vaccination in the elderly

E Corsini, L Vismara, L Lucchi, B Viviani… - Journal of leukocyte …, 2006 - academic.oup.com
The present study was designed to determine the correlation among
dehydroepiandrosterone (DHEA), cortisol plasma levels, and immune functionality at the …

T cell responses are better correlates of vaccine protection in the elderly

JE McElhaney, D Xie, WD Hager, MB Barry… - The Journal of …, 2006 - journals.aai.org
It is commonly held that increased risk of influenza in the elderly is due to a decline in the Ab
response to influenza vaccination. This study prospectively evaluated the relationship …