Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

Biological aging is accompanied by increasing morbidity, mortality, and healthcare costs;
however, its molecular mechanisms are poorly understood. Here, we use multi-omic …

By combining transcriptomic data with other data sources, inferences can be made about
functional changes during ageing. Thus, we conducted a meta-analysis on 127 publicly …

Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

Genetic, environmental, and pharmacological interventions into the aging process can
confer resistance to multiple age‐related diseases in laboratory animals, including rhesus …

Some humans age faster than others. Variation in biological aging can be measured in
midlife, but the implications of this variation are poorly understood. We tested associations …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

The global population of older peo-ple is growing at an unprecedented rate, with the number
of people over 65 years of age expected to reach 1.6 billion by 2050. Given that aging is a …

Longer human lives have led to a global burden of late-life disease. However, some older
people experience little ill health, a trait that should be extended to the general population …

Brain imaging can be used to study how individuals' brains are aging, compared against
population norms. This can inform on aspects of brain health; for example, smoking and …