Ageing is a complex, multifaceted process leading to widespread functional decline that
affects every organ and tissue, but it remains unknown whether ageing has a unifying causal …

Age-associated disease and disability are placing a growing burden on society. However,
ageing does not affect people uniformly. Hence, markers of the underlying biological ageing …

Growing elderly populations, sometimes referred to as gray (or silver) tsunami, are an
increasingly serious health and socioeconomic concern for modern societies. Science has …

The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

An increase in the probability of death has been a defining feature of aging, yet human
perinatal mortality starts high and decreases with age. Previous evolutionary models …

Despite increasing research efforts, there is a lack of consensus on defining aging or health.
To understand the underlying processes, and to foster the development of targeted …

Ageing is intrinsically complex, being driven by multiple causal mechanisms. Each
mechanism tends to be partially supported by data indicating that it has a role in the overall …

Background Diagnostics of the human ageing process may help predict future healthcare
needs or guide preventative measures for tackling diseases of older age. We take a …

Immune responses generally decline with age. However, the dynamics of this process at the
individual level have not been characterized, hindering quantification of an individual's …