The development of healthspan-extending pharmaceuticals requires quantitative estimation
of age-related progressive physiological decline. In humans, individual health status can be …

Although survival has been the focus of aging research for many years, the field is rapidly
evolving towards incorporating healthspan and health indices in studies that explore aging …

Human life expectancy has increased dramatically in the last century and as a result also the
prevalence of a variety of age-related diseases and syndromes. One such syndrome is …

We previously quantified frailty in aged mice with frailty index (FI) that used specialized
equipment to measure health parameters. Here we developed a simplified, noninvasive …

This article investigates the effect on the mouse frailty index (FI), of factors known to
influence lifespan and healthspan in mice: strain (short-lived DBA/2J mice vs long-lived …

Although many common diseases occur mostly in old age, the impact of ageing itself on
disease risk and expression often goes unevaluated. To consider the impact of ageing …

Frailty is an age-related condition characterized by a multisystem functional decline,
increased vulnerability to stressors, and adverse health outcomes. Quantifying the degree of …

Frailty is considered a state of high vulnerability for adverse health outcomes for people of
the same age. Those who are frail have higher mortality, worse health outcomes, and use …

Frailty indexes (FIs) provide quantitative measurements of nonspecific health decline and
are particularly useful as longitudinal monitors of morbidity in aging studies. For mouse …

We investigated the reliability of a newly developed clinical frailty index (FI) that measures
frailty based on deficit accumulation in aging mice. FI scores were measured by two different …