Cellular reprogramming is driven by a defined set of transcription factors; however, the
regulatory logic that underlies cell-type specification and diversification remains elusive …

The stochastic dynamics and regulatory mechanisms that govern differentiation of individual
human neural precursor cells (NPC) into mature neurons are currently not fully understood …

Background Investigating cell fate decision and subpopulation specification in the context of
the neural lineage is fundamental to understanding neurogenesis and neurodegenerative …

Human neurons programmed from induced pluripotent stem cells (iPSCs) through
transcription factor (TF) overexpression are widely used to study neuronal differentiation …

This study develops a versatile cell multiplexing and data analysis platform to accelerate
knowledge gain into mechanisms of cell differentiation. We engineer a cell barcoding …

Accurate identification of cell classes across the tissues of living organisms is central in the
analysis of growing atlases of single-cell RNA sequencing (scRNA-seq) data across …

Differentiation of induced pluripotent stem cells (iPSC) towards different neuronal lineages
has enabled diverse cellular models of human neurodevelopment and related disorders …

Direct lineage reprogramming represents a remarkable conversion of cellular and
transcriptome states,,. However, the intermediate stages through which individual cells …

Highlights•Single-cell RNA sequencing revolutionizes systematic classification of neurons.•
Classification by scRNA-seq reveals new neuronal subtypes.•Matching transcriptionally and …

Mutations are acquired frequently, such that each cell's genome inscribes its history of cell
divisions. Common genomic alterations involve loss of heterozygosity (LOH). LOH …