Assembling the tree of life is a major goal of biology, but progress has been hindered by the difficulty and expense of obtaining the orthologous DNA required for accurate and fully …
Background Differences in gene expression drive phenotypic differences between species, yet major organs and tissues generally have conserved gene expression programs. Several …
Dissecting genomic diversity, one cell at a time | Nature Methods Skip to main content Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To …
Recent years have seen a revolution in single-cell RNA-sequencing (scRNA-seq) technologies, datasets, and analysis methods. Since 2016, the scRNA-tools database has …
MA Brennan, AZ Rosenthal - Frontiers in Microbiology, 2021 - frontiersin.org
Clonal bacterial populations exhibit various forms of heterogeneity, including co-occurrence of cells with different morphological traits, biochemical properties, and gene expression …
X Han, R Wang, Y Zhou, L Fei, H Sun, S Lai… - Cell, 2018 - cell.com
Single-cell RNA sequencing (scRNA-seq) technologies are poised to reshape the current cell-type classification system. However, a transcriptome-based single-cell atlas has not …
Genome‐wide analyses and high‐throughput screening was long reserved for biomedical applications and genetic model organisms. With the rapid development of massively parallel …
Single-cell RNA-seq (scRNA-seq) allows researchers to define cell types on the basis of unsupervised clustering of the transcriptome. However, differences in experimental methods …
Among single-cell analysis technologies, single-cell RNA-seq (scRNA-seq) has been one of the front runners in technical inventions. Since its induction, scRNA-seq has been well …