Whole blood DNA methylation analysis reveals respiratory environmental traits involved in COVID-19 severity following SARS-CoV-2 infection

G Barturen, E Carnero-Montoro… - Nature …, 2022 - nature.com
SARS-CoV-2 infection can cause an inflammatory syndrome (COVID-19) leading, in many
cases, to bilateral pneumonia, severe dyspnea, and in~ 5% of these, death. DNA …

Blood DNA methylation and COVID-19 outcomes

J Balnis, A Madrid, KJ Hogan, LA Drake, HC Chieng… - Clinical …, 2021 - Springer
Background There are no prior reports that compare differentially methylated regions of DNA
in blood samples from COVID-19 patients to samples collected before the SARS-CoV-2 …

[HTML][HTML] Epigenome-wide association study of COVID-19 severity with respiratory failure

MC de Moura, V Davalos, L Planas-Serra… - …, 2021 - thelancet.com
Background Patients infected with the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), responsible for the coronavirus disease 2019 (COVID-19), exhibit a wide …

DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome

M Bradic, S Taleb, B Thomas, O Chidiac… - Journal of Translational …, 2022 - Springer
Background COVID-19 infections could be complicated by acute respiratory distress
syndrome (ARDS), increasing mortality risk. We sought to assess the methylome of …

An epigenome‐wide DNA methylation study of patients with COVID‐19

S Zhou, J Zhang, J Xu, F Zhang, P Li… - Annals of human …, 2021 - Wiley Online Library
In the early 2000s, emerging SARS‐CoV‐2, which is highly pathogenic, posed a great threat
to public health. During COVID‐19, epigenetic regulation is deemed to be an important part …

Longitudinal study of DNA methylation and epigenetic clocks prior to and following test-confirmed COVID-19 and mRNA vaccination

APS Pang, AT Higgins-Chen, F Comite, I Raica… - Frontiers in …, 2022 - frontiersin.org
The host epigenetic landscape rapidly changes during SARS-CoV-2 infection, and evidence
suggest that severe COVID-19 is associated with durable scars to the epigenome …

Identification of COVID-19-associated DNA methylation variations by integrating methylation array and scRNA-Seq data at cell-type resolution

G Wang, Z Xiong, F Yang, X Zheng, W Zong, R Li… - Genes, 2022 - mdpi.com
Single-cell transcriptome studies have revealed immune dysfunction in COVID-19 patients,
including lymphopenia, T cell exhaustion, and increased levels of pro-inflammatory …

A machine learning approach utilizing DNA methylation as an accurate classifier of COVID-19 disease severity

S Bowler, G Papoutsoglou, A Karanikas… - Scientific Reports, 2022 - nature.com
Since the onset of the COVID-19 pandemic, increasing cases with variable outcomes
continue globally because of variants and despite vaccines and therapies. There is a need …

Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19

MJ Corley, APS Pang, K Dody, PA Mudd… - Journal of leukocyte …, 2021 - academic.oup.com
The global pandemic caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is a highly pathogenic RNA virus causing coronavirus disease 2019 (COVID …

Host methylation predicts SARS-CoV-2 infection and clinical outcome

IR Konigsberg, B Barnes, M Campbell… - Communications …, 2021 - nature.com
Background Since the onset of the SARS-CoV-2 pandemic, most clinical testing has focused
on RT-PCR. Host epigenome manipulation post coronavirus infection,–suggests that DNA …