Abstract Changes in gene regulation frequently underlie changes in morphology during
evolution, and differences in chromatin state have been linked with changes in anatomical …

Germ cell development is controlled by unique gene expression programs and involves
epigenetic reprogramming of histone modifications and DNA methylation. The central event …

Histone-modifying enzymes are required for cell identity and lineage commitment, however
little is known about the regulatory origins of the epigenome during embryonic development …

In mammals, all somatic development originates from lineage segregation in early embryos.
However, the dynamics of transcriptomes and epigenomes acting in concert with initial cell …

In multicellular organisms, germ cells carry the hereditary material from one generation to
the next. Developing germ cells are unipotent gamete precursors, and mature gametes are …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

In higher eukaryotes, histone methylation is involved in maintaining cellular identity during
somatic development. As most nucleosomes are replaced by protamines during …

Induction of mouse germ cells occurs from the proximal epiblast at around embryonic day
(E) 7.0. These germ cells then migrate to, and enter the gonads at about E10. 5 after which …

Epigenetic regulation defines the commitment and potential of cells, including the limitations
in their competence to respond to inducing signals. This review discusses the …

Paternal epigenetic inheritance is gaining attention for its growing medical relevance.
However, the form in which paternal epigenetic information is transmitted to offspring and …