Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

The global population of individuals over the age of 65 is growing at an unprecedented rate
and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple …

Leading biologists and clinicians interested in aging convened to discuss biomarkers of
aging. The goals were to come to a consensus, construct an agenda for future research, and …

With the rapid expansion of aging biology research, the identification and evaluation of
longevity interventions in humans have become key goals of this field. Biomarkers of aging …

The aging process has been linked to the occurrence of chronic diseases and functional
impairments, including cancer, sarcopenia, frailty, metabolic, cardiovascular, and …

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

Much progress has been made in the past decades in unraveling the mechanisms that are
responsible for aging. The discovery that particular gene mutations in experimental species …

Aging results in various deleterious changes in the human body that may lead to loss of
function and the manifestation of chronic diseases. While diseases can generally be reliably …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

Despite increasing research efforts, there is a lack of consensus on defining aging or health.
To understand the underlying processes, and to foster the development of targeted …