Iterative transfer learning with neural network for clustering and cell type classification in single-cell RNA-seq analysis

J Hu, X Li, G Hu, Y Lyu, K Susztak, M Li - Nature machine intelligence, 2020 - nature.com
Clustering and cell type classification are important steps in single-cell RNA-seq (scRNA-
seq) analysis. As more and more scRNA-seq data are becoming available, supervised cell …

scID uses discriminant analysis to identify transcriptionally equivalent cell types across single-cell RNA-seq data with batch effect

K Boufea, S Seth, NN Batada - IScience, 2020 - cell.com
The power of single-cell RNA sequencing (scRNA-seq) stems from its ability to uncover cell
type-dependent phenotypes, which rests on the accuracy of cell type identification. However …

SuperCT: a supervised-learning framework for enhanced characterization of single-cell transcriptomic profiles

P Xie, M Gao, C Wang, J Zhang, P Noel… - Nucleic acids …, 2019 - academic.oup.com
Abstract Characterization of individual cell types is fundamental to the study of multicellular
samples. Single-cell RNAseq techniques, which allow high-throughput expression profiling …

A web server for comparative analysis of single-cell RNA-seq data

A Alavi, M Ruffalo, A Parvangada, Z Huang… - Nature …, 2018 - nature.com
Abstract Single cell RNA-Seq (scRNA-seq) studies profile thousands of cells in
heterogeneous environments. Current methods for characterizing cells perform …

Autoencoder-based cluster ensembles for single-cell RNA-seq data analysis

TA Geddes, T Kim, L Nan, JG Burchfield, JYH Yang… - BMC …, 2019 - Springer
Background Single-cell RNA-sequencing (scRNA-seq) is a transformative technology,
allowing global transcriptomes of individual cells to be profiled with high accuracy. An …

scCATCH: automatic annotation on cell types of clusters from single-cell RNA sequencing data

X Shao, J Liao, X Lu, R Xue, N Ai, X Fan - Iscience, 2020 - cell.com
Recent advancements in single-cell RNA sequencing (scRNA-seq) have facilitated the
classification of thousands of cells through transcriptome profiling, wherein accurate cell …

A comprehensive comparison of supervised and unsupervised methods for cell type identification in single-cell RNA-seq

X Sun, X Lin, Z Li, H Wu - Briefings in bioinformatics, 2022 - academic.oup.com
The cell type identification is among the most important tasks in single-cell RNA-sequencing
(scRNA-seq) analysis. Many in silico methods have been developed and can be roughly …

Evaluation of some aspects in supervised cell type identification for single-cell RNA-seq: classifier, feature selection, and reference construction

W Ma, K Su, H Wu - Genome biology, 2021 - Springer
Background Cell type identification is one of the most important questions in single-cell RNA
sequencing (scRNA-seq) data analysis. With the accumulation of public scRNA-seq data …

scClassify: sample size estimation and multiscale classification of cells using single and multiple reference

Y Lin, Y Cao, HJ Kim, A Salim, TP Speed… - Molecular systems …, 2020 - embopress.org
Automated cell type identification is a key computational challenge in single‐cell RNA‐
sequencing (sc RNA‐seq) data. To capitalise on the large collection of well‐annotated sc …

Deep learning enables accurate clustering with batch effect removal in single-cell RNA-seq analysis

X Li, K Wang, Y Lyu, H Pan, J Zhang… - Nature …, 2020 - nature.com
Single-cell RNA sequencing (scRNA-seq) can characterize cell types and states through
unsupervised clustering, but the ever increasing number of cells and batch effect impose …