Use of correct and incorrect methods of accounting for age in studies of epigenetic accelerated aging: implications and recommendations for best practices

N Krieger, JT Chen, C Testa… - American journal of …, 2023 - academic.oup.com
Motivated by our conduct of a literature review on social exposures and accelerated aging
as measured by a growing number of epigenetic “clocks”(which estimate age via DNA …

Alcohol consumption and methylation-based measures of biological age

JK Kresovich, AM Martinez Lopez… - The Journals of …, 2021 - academic.oup.com
Epigenetic age acceleration is considered a measure of biological aging based on genome-
wide patterns of DNA methylation. Although age acceleration has been associated with the …

Association of DNA methylation-based biological age with health risk factors and overall and cause-specific mortality

PA Dugué, JK Bassett, JHE Joo… - American journal of …, 2018 - academic.oup.com
Measures of biological age based on blood DNA methylation, referred to as age
acceleration (AA), have been developed. We examined whether AA was associated with …

DNA methylation–based measures of biological aging

PA Dugué, S Li, JL Hopper, RL Milne - Epigenetics in human disease, 2018 - Elsevier
Aging is associated with profound changes in DNA methylation. Recent studies have used
DNA methylation to build very accurate age predictors, also named “epigenetic clocks,” that …

Socioeconomic position and DNA methylation age acceleration across the life course

A Hughes, M Smart, T Gorrie-Stone… - American journal of …, 2018 - academic.oup.com
Accelerated DNA methylation age is linked to all-cause mortality and environmental factors,
but studies of associations with socioeconomic position are limited. Researchers generally …

Associations of age, sex, race/ethnicity, and education with 13 epigenetic clocks in a nationally representative US sample: the Health and Retirement Study

EM Crimmins, B Thyagarajan, ME Levine… - The Journals of …, 2021 - academic.oup.com
Background Many DNA methylation-based indicators have been developed as summary
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …

Associations of body composition and physical activity level with multiple measures of epigenetic age acceleration

JK Kresovich, EL Garval… - American journal of …, 2021 - academic.oup.com
Epigenetic clocks use DNA methylation to estimate biological age. Whether body
composition and physical activity are associated with these clocks is not well understood …

Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality

JD Faul, JK Kim, ME Levine… - Proceedings of the …, 2023 - National Acad Sciences
Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …

[HTML][HTML] A systematic review of biological, social and environmental factors associated with epigenetic clock acceleration

L Oblak, J van der Zaag, AT Higgins-Chen… - Ageing research …, 2021 - Elsevier
Aging involves a diverse set of biological changes accumulating over time that leads to
increased risk of morbidity and mortality. Epigenetic clocks are now widely used to quantify …

A systematic review and meta-analysis of environmental, lifestyle, and health factors associated with DNA methylation age

J Ryan, J Wrigglesworth, J Loong… - The Journals of …, 2020 - academic.oup.com
DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an
individual's chronological age and can predict their risk of age-related disease and mortality …