The application of human embryonic stem (ES) cells in medicine and biology has an
inherent reliance on understanding the starting cell population. Human ES cells differ from …

Although the first mouse embryonic stem (ES) cell lines were derived 25 years ago, using
feeder-layer-based blastocyst cultures, subsequent efforts to extend the approach to other …

Diploidy is a fundamental genetic feature in mammals, in which haploid cells normally arise
only as post-meiotic germ cells that serve to ensure a diploid genome upon fertilization …

The pluripotent state, which is first established in the primitive ectoderm cells of blastocysts,
is lost progressively and irreversibly during subsequent development. For example …

Mouse embryonic stem cells derived from the epiblast contribute to the somatic lineages and
the germline but are excluded from the extra-embryonic tissues that are derived from the …

The human embryo undergoes morphogenetic transformations following implantation into
the uterus, but our knowledge of this crucial stage is limited by the inability to observe the …

Pluripotential stem cells, present in the early stages of embryo development, can generate
all of the cell types in a fetus and in the adult and are capable of self-renewal. A renewable …

The most basic objection to human embryonic stem (ES) cell research is rooted in the fact
that ES cell derivation deprives embryos of any further potential to develop into a complete …

The epiblast is the mammalian embryonic tissue that contains the pluripotent stem cells that
generate the whole embryo. We have established a method for inducing functional genetic …

Embryonic stem (ES) cells are cells derived from the early embryo that can be propagated
indefinitely in the primitive undifferentiated state while remaining pluripotent; they share …