Alzheimer's disease: an updated overview of its genetics

J Andrade-Guerrero, A Santiago-Balmaseda… - International journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is
classified as familial and sporadic. The dominant familial or autosomal presentation …

Genetics of Alzheimer's disease: From pathogenesis to clinical usage

W Shao, D Peng, X Wang - Journal of Clinical Neuroscience, 2017 - Elsevier
Alzheimer's disease (AD) is the most common type of dementia and has caused a major
global health concern. Understanding the etiology of AD can be beneficial for the diagnosis …

The genetic landscape of Alzheimer disease: clinical implications and perspectives

C Van Cauwenberghe, C Van Broeckhoven… - Genetics in …, 2016 - nature.com
The search for the genetic factors contributing to Alzheimer disease (AD) has evolved
tremendously throughout the years. It started from the discovery of fully penetrant mutations …

The genetics of A lzheimer's disease; putting flesh on the bones

C Medway, K Morgan - Neuropathology and applied …, 2014 - Wiley Online Library
For two decades the search for genes involved in A lzheimer's disease brought little reward;
it was not until the advent of genome‐wide association studies (GWAS) that genetic …

Molecular genetics of Alzheimer's disease: an update

N Brouwers, K Sleegers, C Van Broeckhoven - Annals of medicine, 2008 - Taylor & Francis
Alzheimer's disease (AD) is a complex disorder of the central nervous system (CNS).
Molecular genetic research has provided a wealth of information regarding the genetic …

Genomic variants, genes, and pathways of Alzheimer's disease: An overview

AC Naj, GD Schellenberg… - American Journal of …, 2017 - Wiley Online Library
Alzheimer's disease (AD)(MIM: 104300) is a highly heritable disease with great complexity
in its genetic contributors, and represents the most common form of dementia. With the …

[HTML][HTML] Genetics of Alzheimer's disease: where we are, and where we are going

C Bellenguez, B Grenier-Boley, JC Lambert - Current opinion in …, 2020 - Elsevier
Highlights•More than 40 loci of interest have been associated with the risk of developing
AD.•Recent genetic data clearly implicate microglia as involved in the pathophysiological …

The genetics of Alzheimer's disease

E Bagyinszky, YC Youn, SSA An… - Clinical interventions in …, 2014 - Taylor & Francis
Alzheimer's disease (AD) is a complex and heterogeneous neurodegenerative disorder,
classified as either early onset (under 65 years of age), or late onset (over 65 years of age) …

The genetic landscape of Alzheimer disease

S Carmona, J Hardy, R Guerreiro - Handbook of clinical neurology, 2018 - Elsevier
Alzheimer disease (AD), a progressive and neurodegenerative disease, is the most common
form of dementia with high incidence in elderly people. Neuropathologically the disease is …

Genetics of Alzheimer disease in the pre-and post-GWAS era

N Ertekin-Taner - Alzheimer's research & therapy, 2010 - Springer
Since the 1990s, the genetics of Alzheimer disease (AD) has been an active area of
research. The identification of deterministic mutations in the APP, PSEN1, and PSEN2 …