Cellular senescence is a process that leads to a state of irreversible cell growth arrest
induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate …

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …

Aging is the most important single risk factor for many chronic diseases such as cancer,
metabolic syndrome, and neurodegenerative disorders. Targeting aging itself might …

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Senescence is linked to a wide range of age-associated diseases and physiological
declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of …

Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

The influence of the activation of a cellular phenotype termed senescence and it's
importance in ageing and age-related diseases is becoming more and more evident. In fact …

Senescence is the consequence of a signaling mechanism activated in stressed cells to
prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a …