Aging has been targeted by genetic and dietary manipulation and by drugs in order to
increase lifespan and health span in numerous models. Metformin, which has demonstrated …

In a world where the population is ageing, there is growing interest and demand for research
evaluating strategies that address the ageing process. After 60 years of successful use of …

The numerous beneficial health outcomes associated with the use of metformin to treat
patients with type 2 diabetes (T2DM), together with data from pre-clinical studies in animals …

Even though the inevitable process of aging by itself cannot be considered a disease, it is
directly linked to life span and is the driving force behind all age-related diseases. It is an …

Metformin is a safe, effective and useful drug for glucose management in patients with
diabetes. However in recent years, more attention has been paid to the possibility of using …

Metformin is the most widely prescribed oral hypoglycemic medication for type 2 diabetes
worldwide. Metformin also retards aging in model organisms and reduces the incidence of …

Metformin is sometimes proposed to be an “anti-aging” drug, based on preclinical
experiments with lower-order organisms and numerous retrospective data on beneficial …

Aging is a universal phenomenon in all biological organisms, defined by the loss of
reproductive capacity and a progressive decline in fitness. In humans, aging is further …

Administration of metformin increases healthspan and lifespan in model systems, and
evidence from clinical trials and observational studies suggests that metformin delays a …

Metformin is a drug commonly prescribed to treat patients with type 2 diabetes. Here we
show that long-term treatment with metformin (0.1% w/w in diet) starting at middle age …