The enormous variation in human lifespan is in part due to a myriad of sequence variants,
only a few of which have been revealed to date. Since many life-shortening events are …

Aging populations face diminishing quality of life due to increased disease and morbidity.
These challenges call for longevity research to focus on understanding the pathways …

Background Family studies and heritability estimates provide evidence for a genetic
contribution to variation in the human life span. Methods We conducted a genome wide …

Ageing phenotypes, such as years lived in good health (healthspan), total years lived
(lifespan), and survival until an exceptional old age (longevity), are of interest to us all but …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

We developed a new statistical framework to find genetic variants associated with extreme
longevity. The method, informed GWAS (iGWAS), takes advantage of knowledge from large …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …

We undertook a genome-wide association study (GWAS) of parental longevity in European
descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci …

We present a massive investigation into the genetic basis of human lifespan. Beginning with
a genome-wide association (GWA) study using a de-identified snapshot of the unique …

Despite notable progress of the candidate-gene and genome-wide association studies
(GWAS), understanding the role of genes contributing to human health and lifespan is still …