Role of DNA methylation in colorectal carcinogenesis

ÁV Patai, B Molnár, A Kalmár, A Schöller, K Tóth… - Digestive …, 2012 - karger.com
Colorectal cancer is the most common malignancy of the gastrointestinal tract and a leading
cause of cancer-related deaths worldwide. In order to detect early precursor lesions …

[HTML][HTML] Accumulation of aberrant DNA methylation during colorectal cancer development

E Sakai, A Nakajima, A Kaneda - World Journal of …, 2014 - ncbi.nlm.nih.gov
Despite the recent advances in the therapeutic modalities, colorectal cancer (CRC) remains
to be one of the most common causes of cancer-related death. CRC arises through …

Methods for genome-wide analysis of DNA methylation in intestinal tumors

MA Hahn, GP Pfeifer - Mutation Research/Fundamental and Molecular …, 2010 - Elsevier
Recent studies show that colorectal cancer is strongly associated with aberrant DNA
methylation, which has been linked to the origin and progression of the disease. This fact …

Epigenetics and colorectal cancer

VV Lao, WM Grady - Nature reviews Gastroenterology & hepatology, 2011 - nature.com
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. It results from an
accumulation of genetic and epigenetic changes in colon epithelial cells, which transforms …

DNA methylation patterns as noninvasive biomarkers and targets of epigenetic therapies in colorectal cancer

Y Hashimoto, TJ Zumwalt, A Goel - Epigenomics, 2016 - Taylor & Francis
Aberrant DNA methylation is frequently detected in gastrointestinal tumors, and can
therefore potentially be used to screen, diagnose, prognosticate, and predict colorectal …

DNA methylation in colorectal cancer—impact on screening and therapy monitoring modalities?

M Zitt, M Zitt, HM Müller - Disease markers, 2007 - Wiley Online Library
Colorectal cancer (CRC) is a common malignancy. It arises from benign neoplasms and
evolves into adenocarcinomas through a stepwise histological progression sequence …

Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation

F Coppedè - Cancer letters, 2014 - Elsevier
The original theory of the multi-step process of colorectal cancer (CRC), suggesting that the
disease resulted from the accumulation of mutations in oncogenes and tumor suppressor …

DNA methylation change profiling of colorectal disease: screening towards clinical use

JM Yi - Life, 2021 - mdpi.com
Colon cancer remains one of the leading causes of cancer-related deaths worldwide.
Transformation of colon epithelial cells into invasive adenocarcinomas has been well known …

Aberrant DNA methylation in colorectal cancer: what should we target?

JWT Tse, LJ Jenkins, F Chionh, JM Mariadason - Trends in cancer, 2017 - europepmc.org
Colorectal cancers (CRCs) are characterized by global hypomethylation and promoter-
specific DNA methylation. A subset of CRCs with extensive and co-ordinate patterns of …

Aberrant DNA methylation in colorectal cancer: what should we target?

WT Janson, LJ Jenkins, F Chionh, JM Mariadason - Trends in cancer, 2017 - cell.com
Colorectal cancers (CRCs) are characterized by global hypomethylation and promoter-
specific DNA methylation. A subset of CRCs with extensive and co-ordinate patterns of …