Aging is the key risk factor for cognitive decline, yet the molecular changes underlying brain
aging remain poorly understood. Here, we conducted spatiotemporal RNA sequencing of …

The diversity and complex organization of cells in the brain have hindered systematic
characterization of age-related changes in its cellular and molecular architecture, limiting …

The mammalian brain is complex, with multiple cell types performing a variety of diverse
functions, but exactly how each cell type is affected in aging remains largely unknown. Here …

Aging is associated with complex molecular and cellular processes that are poorly
understood. Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set to …

The hippocampus plays a crucial role in learning and memory, and its progressive
deterioration with age is functionally linked to a variety of human neurodegenerative …

The diversity of cell types is a challenge for quantifying aging and its reversal. Here we
develop 'aging clocks' based on single-cell transcriptomics to characterize cell-type-specific …

Background Recent studies have revealed diverse Alzheimer's disease (AD)‐associated
brain cell states, yet when and how they impact the causal chain leading to AD remains …

Aging is associated with gradual deterioration of physiological and biochemical functions,
including cognitive decline. Transcriptome profiling of brain samples from individuals of …

Aging is regarded as a major risk factor for neurodegenerative diseases. Thus, a better
understanding of the similarities between the aging process and neurodegenerative …

Alzheimer's disease and other neurodegenerative disorders of aging are characterized by
clinical and pathological features that are relatively specific to humans. To obtain greater …