Emerging insights into the metabolic alterations in aging using metabolomics

S Srivastava - Metabolites, 2019 - mdpi.com
Metabolomics is the latest 'omics' technology and systems biology science that allows for
comprehensive profiling of small-molecule metabolites in biological systems at a specific …

The metabolomics of human aging: Advances, challenges, and opportunities

DJ Panyard, B Yu, MP Snyder - Science Advances, 2022 - science.org
As the global population becomes older, understanding the impact of aging on health and
disease becomes paramount. Recent advancements in multiomic technology have allowed …

[HTML][HTML] Metabolomics signatures of aging: recent advances

SS Adav, Y Wang - Aging and disease, 2021 - ncbi.nlm.nih.gov
Metabolomics is the latest state-of-the-art omics technology that provides a comprehensive
quantitative profile of metabolites. The metabolites are the cellular end products of metabolic …

Precise metabolomics reveals a diversity of aging‐associated metabolic features

H Tian, Z Ni, SM Lam, W Jiang, F Li, J Du… - Small …, 2022 - Wiley Online Library
Mass spectrometry‐based metabolomics has emerged as a powerful technique for
biomedical research, although technical issues with its analytical precision and structural …

The potential of metabolomics in biomedical applications

V Gonzalez-Covarrubias, E Martínez-Martínez… - Metabolites, 2022 - mdpi.com
The metabolome offers a dynamic, comprehensive, and precise picture of the phenotype.
Current high-throughput technologies have allowed the discovery of relevant metabolites …

The plasma metabolome as a predictor of biological aging in humans

LC Johnson, K Parker, BF Aguirre, TG Nemkov… - Geroscience, 2019 - Springer
Chronological age is an important predictor of morbidity and mortality; however, it is unable
to account for heterogeneity in the decline of physiological function and health with …

Whole blood metabolomics in aging research

H Kondoh, M Kameda, M Yanagida - International journal of molecular …, 2020 - mdpi.com
Diversity is observed in the wave of global aging because it is a complex biological process
exhibiting individual variability. To assess aging physiologically, markers for biological aging …

Human serum metabolic profiles are age dependent

Z Yu, G Zhai, P Singmann, Y He, T Xu, C Prehn… - Aging cell, 2012 - Wiley Online Library
Understanding the complexity of aging is of utmost importance. This can now be addressed
by the novel and powerful approach of metabolomics. However, to date, only a few …

Exploring disease through metabolomics

N Vinayavekhin, EA Homan… - ACS chemical biology, 2010 - ACS Publications
Metabolomics approaches provide an analysis of changing metabolite levels in biological
samples. In the past decade, technical advances have spurred the application of …

Serum metabolomic profiling in aging mice using liquid chromatography—mass spectrometry

T Yue, H Tan, Y Shi, M Xu, S Luo, J Weng, S Xu - Biomolecules, 2022 - mdpi.com
Background: The process of aging and metabolism are intricately linked, thus rendering the
identification of reliable biomarkers related to metabolism crucial for delaying the aging …