Network medicine links SARS-CoV-2/COVID-19 infection to brain microvascular injury and neuroinflammation in dementia-like cognitive impairment

Y Zhou, J Xu, Y Hou, JB Leverenz, A Kallianpur… - Alzheimer's research & …, 2021 - Springer
Background Dementia-like cognitive impairment is an increasingly reported complication of
SARS-CoV-2 infection. However, the underlying mechanisms responsible for this …

COVID-19 and Alzheimer's disease: How one crisis worsens the other

X Xia, Y Wang, J Zheng - Translational Neurodegeneration, 2021 - Springer
Alzheimer's disease (AD) has emerged as a key comorbidity of coronavirus disease 2019
(COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) …

COVID-19 as a Risk Factor for Alzheimer's Disease

M Golzari-Sorkheh, DF Weaver… - Journal of Alzheimer's …, 2023 - content.iospress.com
Severe acute respiratory disease coronavirus 2 (SARS-CoV-2) is responsible for the
coronavirus disease 2019 (COVID-19) pandemic. Although a primarily respiratory disease …

Recapitulation of pathophysiological features of AD in SARS-CoV-2-infected subjects

E Griggs, K Trageser, S Naughton, EJ Yang, B Mathew… - Elife, 2023 - elifesciences.org
Infection with the etiological agent of COVID-19, SARS-CoV-2, appears capable of
impacting cognition in some patients with post-acute sequelae of SARS-CoV-2 (PASC). To …

COVID-19 and Alzheimer's disease

M Ciaccio, B Lo Sasso, C Scazzone, CM Gambino… - Brain sciences, 2021 - mdpi.com
The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a neurotropic
virus with a high neuroinvasive potential. Indeed, more than one-third of patients develop …

SARS-CoV-2 infection increases the gene expression profile for Alzheimer's disease risk

R Green, K Mayilsamy, AR McGill, TE Martinez… - … Therapy-Methods & …, 2022 - cell.com
The coronavirus disease 2019 (COVID-19) pandemic has caused over 600,000,000
infections globally thus far. Up to 30% of individuals with mild to severe disease develop …

SARS-CoV-2-mediated neuropathogenesis, deterioration of hippocampal neurogenesis and dementia

RK Radhakrishnan… - American Journal of …, 2022 - journals.sagepub.com
A significant portion of COVID-19 patients and survivors display marked clinical signs of
neurocognitive impairments. SARS-CoV-2-mediated peripheral cytokine storm and its …

Brain disease network analysis to elucidate the neurological manifestations of COVID-19

K Prasad, SY AlOmar, SAM Alqahtani, MZ Malik… - Molecular …, 2021 - Springer
Although COVID-19 largely causes respiratory complications, it can also lead to various
extrapulmonary manifestations resulting in higher mortality and these comorbidities are …

Human brain microvascular endothelial cells exposure to SARS-CoV-2 leads to inflammatory activation through NF-κB non-canonical pathway and mitochondrial …

CS Motta, S Torices, BG da Rosa, AC Marcos… - Viruses, 2023 - mdpi.com
Neurological effects of COVID-19 and long-COVID-19, as well as neuroinvasion by SARS-
CoV-2, still pose several questions and are of both clinical and scientific relevance. We …

Inflammation at the crossroads of COVID-19, cognitive deficits and depression

NML e Silva, FGQ Barros-Aragão, FG De Felice… - …, 2022 - Elsevier
Acute neurological alterations have been associated with SARS-CoV-2 infection.
Additionally, it is becoming clear that coronavirus disease 2019 (COVID-19) survivors may …