COVID‐19 is an emergent disease of aging
COVID‐19 is an ongoing pandemic caused by the SARS‐CoV‐2 coronavirus that poses one
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …
of the greatest challenges to public health in recent years. SARS‐CoV‐2 is known to …
[HTML][HTML] Molecular and cellular immune features of aged patients with severe COVID-19 pneumonia
D Lo Tartaro, A Neroni, A Paolini, R Borella… - Communications …, 2022 - nature.com
Aging is a major risk factor for developing severe COVID-19, but few detailed data are
available concerning immunological changes after infection in aged individuals. Here we …
available concerning immunological changes after infection in aged individuals. Here we …
SARS-CoV-2 spike protein induces paracrine senescence and leukocyte adhesion in endothelial cells
Increased mortality in COVID-19 cases is often associated with microvascular complications.
We have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
We have recently shown that severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2
L Heydemann, M Ciurkiewicz, G Beythien… - Nature …, 2023 - nature.com
COVID-19 survivors often suffer from post-acute sequelae of SARS-CoV-2 infection (PASC).
Current evidence suggests dysregulated alveolar regeneration as a possible explanation for …
Current evidence suggests dysregulated alveolar regeneration as a possible explanation for …
SARS-CoV-2 rapidly adapts in aged BALB/c mice and induces typical pneumonia
Y Zhang, K Huang, T Wang, F Deng, W Gong… - Journal of …, 2021 - Am Soc Microbiol
Age is a risk factor for coronavirus disease 2019 (COVID-19)-associated morbidity and
mortality in humans; hence, in this study, we compared the course of severe acute …
mortality in humans; hence, in this study, we compared the course of severe acute …
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19
F D'Agnillo, KA Walters, Y Xiao, ZM Sheng… - Science translational …, 2021 - science.org
Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …
coronavirus 2 (SARS-CoV-2), is characterized by respiratory distress, multiorgan …
Pathogenesis of COVID-19-induced ARDS: implications for an ageing population
MAT Acosta, BD Singer - European Respiratory Journal, 2020 - Eur Respiratory Soc
The coronavirus disease 2019 (COVID-19) pandemic has elicited a swift response by the
scientific community to elucidate the pathogenesis of severe acute respiratory syndrome …
scientific community to elucidate the pathogenesis of severe acute respiratory syndrome …
Multisystemic cellular tropism of SARS-CoV-2 in autopsies of COVID-19 patients
Multiorgan tropism of SARS-CoV-2 has previously been shown for several major organs. We
have comprehensively analyzed 25 different formalin-fixed paraffin-embedded (FFPE) …
have comprehensively analyzed 25 different formalin-fixed paraffin-embedded (FFPE) …
TNF‐α/IFN‐γ synergy amplifies senescence‐associated inflammation and SARS‐CoV‐2 receptor expression via hyper‐activated JAK/STAT1
R Kandhaya‐Pillai, X Yang, T Tchkonia, GM Martin… - Aging cell, 2022 - Wiley Online Library
Older age and underlying conditions such as diabetes/obesity or immunosuppression are
leading host risk factors for developing severe complications from COVID‐19 infection. The …
leading host risk factors for developing severe complications from COVID‐19 infection. The …
Immune signatures underlying post-acute COVID-19 lung sequelae
Severe coronavirus disease 2019 (COVID-19) pneumonia survivors often exhibit long-term
pulmonary sequelae, but the underlying mechanisms or associated local and systemic …
pulmonary sequelae, but the underlying mechanisms or associated local and systemic …