[HTML][HTML] In situ detection of SARS-CoV-2 in lungs and airways of patients with COVID-19
IM Schaefer, RF Padera, IH Solomon, S Kanjilal… - Modern Pathology, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 has led to a global
public health crisis. In elderly individuals and those with comorbidities, COVID-19 is …
public health crisis. In elderly individuals and those with comorbidities, COVID-19 is …
Probing long COVID through a proteomic lens: a comprehensive two-year longitudinal cohort study of hospitalised survivors
X Gu, S Wang, W Zhang, C Li, L Guo, Z Wang, H Li… - …, 2023 - thelancet.com
Background As a debilitating condition that can impact a whole spectrum of people and
involve multi-organ systems, long COVID has aroused the most attention than ever …
involve multi-organ systems, long COVID has aroused the most attention than ever …
[HTML][HTML] Why does COVID-19 disproportionately affect older people?
AL Mueller, MS McNamara, DA Sinclair - Aging (albany NY), 2020 - ncbi.nlm.nih.gov
The severity and outcome of coronavirus disease 2019 (COVID-19) largely depends on a
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
patient's age. Adults over 65 years of age represent 80% of hospitalizations and have a 23 …
Aging & COVID-19 susceptibility, disease severity, and clinical outcomes: The role of entangled risk factors
M Farshbafnadi, SK Zonouzi, M Sabahi… - Experimental …, 2021 - Elsevier
Abstract The emergence of Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-
2) in late 2019 has been associated with a high rate of mortality and morbidity. It has been …
2) in late 2019 has been associated with a high rate of mortality and morbidity. It has been …
Senolytics reduce coronavirus-related mortality in old mice
INTRODUCTION The COVID-19 pandemic revealed enhanced vulnerability of the elderly
and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus …
and chronically ill to adverse outcomes upon severe acute respiratory syndrome coronavirus …
COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes
SARS-CoV-2 infection can cause persistent respiratory sequelae. However, the underlying
mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 …
mechanisms remain unclear. Here we report that sub-lethally infected K18-human ACE2 …
COVID-19 lung pathogenesis in SARS-CoV-2 autopsy cases
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a major public health
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …
issue. COVID-19 is considered an airway/multi-systemic disease, and demise has been …
Immunosenescence exacerbates the COVID-19
Aging and senescence are complex processes associated with increased frailty (Calimport,
Bentley, & Stewart, 2019). Overall, many pathogens are more aggressive and prevalent in …
Bentley, & Stewart, 2019). Overall, many pathogens are more aggressive and prevalent in …
Age-dependent assessment of genes involved in cellular senescence, telomere, and mitochondrial pathways in human lung tissue of smokers, COPD, and IPF …
Background Aging is one of the key contributing factors for chronic obstructive pulmonary
diseases (COPD) and other chronic inflammatory lung diseases. Here, we determined how …
diseases (COPD) and other chronic inflammatory lung diseases. Here, we determined how …
[HTML][HTML] ACE2 and COVID-19 Susceptibility and Severity
M Zheng - Aging and disease, 2022 - ncbi.nlm.nih.gov
Sick, male, and older populations are more vulnerable to COVID-19. However, it remains
unclear whether a common mechanism exists across different demographic characteristics …
unclear whether a common mechanism exists across different demographic characteristics …