The generation of neocortical neurons from neural progenitor cells (NPCs) is primarily
controlled by transcription factors binding to DNA in the context of chromatin. To understand …

During embryonic brain development, neural progenitor/stem cells (NPCs) sequentially give
rise to different subtypes of neurons and glia via a highly orchestrated process. To …

Regulation of the epigenome during in vivo specification of brain stem cells is still poorly
understood. Here, we report DNA methylome analyses of directly sampled cortical neural …

The cerebral cortex is formed by diverse neurons generated sequentially from neural stem
cells (NSCs). A clock mechanism has been suggested to underlie the temporal progression …

How multiple epigenetic layers and transcription factors (TFs) interact to facilitate brain
development is largely unknown. Here, to systematically map the regulatory landscape of …

A comprehensive characterization of epigenomic organization in the embryonic mouse
forebrain will enhance our understanding of neurodevelopment and provide insight into …

Unraveling the mechanisms by which neural stem cells generate distinct cell types remains
a central challenge in central nervous system (CNS) biology. Recent studies have shown …

During embryonic brain development, neurogenesis requires the orchestration of gene
expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with …

Neural stem cells (NSCs) have the ability to self-renew and give rise to neurons and glial
cells (astrocytes and oligodendrocytes) in the mammalian central nervous system. This …

Neural stem cells (NSCs) possess the ability to self-renew and to differentiate along
neuronal and glial lineages. These processes are defined by the dynamic interplay between …