A well-established feature of physiological ageing is altered immune function, a
phenomenon termed immunesenescence. Thought to be responsible in part for the …

Immunosenescence, describing alterations, including decline of immune responses with
age, is comprised of inappropriate elevations, decreases, and dysregulated immune …

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age …

The aging immune system demonstrates a reduced capacity to mount a robust immune
response (immunosenescence), thereby increasing the susceptibility to various infectious …

Adaptive immunity undergoes severe deterioration with age and represents the main
problem in the elderly. However, evidence accumulated over the last decade supports the …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …

Advancing age is accompanied by profound changes in immune function; some are induced
by the loss of critical niches that support development of naïve cells (eg thymic involution) …

Advanced age is associated with defects in all of the cells of the innate immune system,
including numbers, function, and early stages of activation. This review, presents the current …

Like all somatic tissues, the human immune system changes with age. This is believed to
result in an increased frequency of, and susceptibility to, infectious disease and to contribute …