Cisplatin-based chemotherapy has been used for more than four decades as a standard
therapeutic option in several tumor entities. However, being a multifaceted and …

Abstract cis-Diammine-dichloro-platinumII (cisplatin) is an inorganic, square-planar
coordination complex that has become one of the most important drugs in the clinical …

Although cisplatin has been a pivotal chemotherapy drug in treating patients with various
types of cancer for decades, drug resistance has been a major clinical impediment. In …

Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor
cells can acquire resistance to the damage caused by cisplatin, generating genetic and …

Cisplatin-based chemotherapeutic regimens are frequently used for treatments of solid
tumors. However, tumor cells may have inherent or acquired cisplatin resistance, and the …

Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of
cancer types. Unfortunately, many cancers initially respond to platinum treatment but when …

Intrinsic or acquired resistance to anticancer agents is a major obstacle to the success of
chemotherapy. Anticancer agents are known to modulate signal transduction pathways and …

Background Cisplatin is widely used for chemotherapy of head and neck squamous cell
carcinoma. However, details of the molecular mechanism responsible for cisplatin …

Cisplatin and carboplatin are among the most active and widely used cytotoxic anticancer
drugs. However, the acquisition or presence of resistance significantly undermines the …

Cisplatin is a chemotherapy drug that kills cancer cells by damaging their DNA. In human
cells, this damage is repaired primarily by nucleotide excision repair. While cisplatin is …