In spite of a growing body of research and data, human ageing remains a poorly understood
process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR) …

Aging is a major worldwide medical challenge. Not surprisingly, identifying drugs and
compounds that extend lifespan in model organisms is a growing research area. Here, we …

Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …

Biological aging is associated with a reduction in the reparative and regenerative potential
in tissues and organs. This reduction manifests as a decreased physiological reserve in …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Abstract The Human Ageing Genomic Resources (HAGR) is a collection of online resources
for studying the biology of human ageing. HAGR features two main databases: GenAge and …

Aging is the major biomedical challenge of this century. The percentage of elderly people,
and consequently the incidence of age-related diseases such as heart disease, cancer, and …

Cellular metabolism and environmental interactions generate molecular damage affecting
all levels of biological organization. Accumulation of this damage over time is thought to …

Human aging and longevity are complex and multi-factorial traits that result from a
combination of environmental, genetic, epigenetic and stochastic factors, each contributing …

Background Cellular senescence, a permanent state of replicative arrest in otherwise
proliferating cells, is a hallmark of aging and has been linked to aging-related diseases …