Ageing is the single greatest cause of disease and death worldwide, and understanding the
associated processes could vastly improve quality of life. Although major categories of …

Individuals of the same age may not age at the same rate. Quantitative biomarkers of aging
are valuable tools to measure physiological age, assess the extent of 'healthy aging', and …

Aging is one of the most important biological processes and is a known risk factor for many
age-related diseases in human. Studying age-related transcriptomic changes in tissues …

Genome-wide studies of aging have identified subsets of genes that show age-related
changes in expression. Although the types of genes that are age regulated vary among …

The role of cellular senescence (CS) in age-related diseases (ARDs) is a quickly emerging
topic in aging research. Our comprehensive data mining revealed over 250 genes tightly …

The development of clinical interventions that significantly improve human healthspan
requires robust markers of biological age as well as thoughtful therapeutic targets. To …

Aging is a complex process that affects multiple organs. Modeling aging and age-related
diseases in the lab is challenging because classical vertebrate models have relatively long …

Genomic instability, telomere attrition, epigenetic alterations, mitochondrial dysfunction, loss
of proteostasis, deregulated nutrient-sensing, cellular senescence, stem cell exhaustion …

Abstract In model organisms, over 2,000 genes have been shown to modulate aging, the
collection of which we call the 'gerontome'. Although some individual aging-related genes …

Abstract The Human Ageing Genomic Resources (HAGR, http://genomics. senescence. info)
is a freely available online collection of research databases and tools for the biology and …