Mounting evidence suggests that DNA damage plays a central role in aging. Multiple tiers of
defense have evolved to reduce the accumulation of DNA damage, including reducing …

Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals
are composed of distinct cell type identities and tissue environments, but the influence of …

Protein synthesis represents a major metabolic activity of the cell. However, how it is affected
by aging and how this in turn impacts cell function remains largely unexplored. To address …

A long-standing model holds that stochastic aberrations of transcriptional regulation play a
key role in the process of ageing. While transcriptional dysregulation is observed in many …

Regulation of gene expression is linked to the organization of the genome. With age,
chromatin alterations occur on all levels of genome organization, accompanied by changes …

Aging is a complex process that results in loss of the ability to reattain homeostasis following
stress, leading, thereby, to increased risk of morbidity and mortality. Many factors contribute …

Ageing is the single greatest cause of disease and death worldwide, and understanding the
associated processes could vastly improve quality of life. Although major categories of …

Abstract Machine learning models based on DNA methylation data can predict biological
age but often lack causal insights. By harnessing large-scale genetic data through …

Ageing leads to dramatic changes in the physiology of many different tissues resulting in a
spectrum of pathology. Nonetheless, many lines of evidence suggest that ageing is driven …

Background Age-associated epigenetic changes are implicated in aging. Notably, age-
associated DNA methylation changes comprise a so-called aging “clock”, a robust …