Genome instability is a fundamentally important component of aging in all eukaryotes. How
age-related genome instability occurs remains unclear. The free radical theory of aging …

Cellular senescence refers to an irreversible state of cell-cycle arrest and plays important
roles in aging and cancer biology. Because senescence is associated with increased cell …

Understanding why we age is a long-standing question, and many mechanistic theories of
aging have been proposed. Owing to limitations in studying the aging process, including a …

Aging is often associated with a loss of cell type identity that results in an increase in
transcriptional noise in aged tissues. If this phenomenon reflects a fundamental property of …

The origin of mutations is central to understanding evolution and of key relevance to health.
Variation occurs non-randomly across the genome, and mechanisms for this remain to be …

DNA methylation dynamics have emerged as a promising biomarker of mammalian aging,
with multivariate machine learning models ('epigenetic clocks') enabling measurement of …

Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …

Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …

Ageing is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. Despite rapid advances over recent years …

Aging is a leading risk factor for cancer. While it is proposed that age-related accumulation
of somatic mutations drives this relationship, it is likely not the full story. We show that aging …