Background Identifying biological pathways that vary across the age spectrum can provide
insight into fundamental mechanisms that impact disease and frailty in the elderly. Few …

Loss of genome maintenance may causally contribute to ageing, as exemplified by the
premature appearance of multiple symptoms of ageing in a growing family of human …

Aging is classically conceptualized as an ever-increasing trajectory of damage accumulation
and loss of function, leading to increases in morbidity and mortality. However, recent in vitro …

Proteostasis collapse, the diminished ability to maintain protein homeostasis, has been
established as a hallmark of nematode aging. However, whether proteostasis collapse …

Aging is associated with complex molecular and cellular processes that are poorly
understood. Here we leveraged the Tabula Muris Senis single-cell RNA-seq data set to …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Aging represents the progressive functional decline and increased mortality risk common to
nearly all metazoans. Recent findings experimentally link DNA damage and organismal …

Over the course of a human lifespan, genome integrity erodes, leading to an increased
abundance of several types of chromatin changes. The abundance of DNA lesions …

Cells are constantly exposed to a variety of environmental and endogenous conditions
causing DNA damage, which is detected and repaired by conserved DNA repair pathways …