It is now well established that the genomic landscape of DNA methylation (DNAm) gets
altered as a function of age, a process we here call 'epigenetic drift'. The biological …

As average life span and elderly people prevalence in the western world population is
gradually increasing, the incidence of age-related diseases such as cancer, heart diseases …

Aging is a mysterious process, not only controlled genetically but also subject to random
damage that can accumulate over time. While DNA damage and subsequent mutation in …

Cellular aging plays an important role in many diseases, such as cancers, metabolic
syndromes, and neurodegenerative disorders. There has been steady progress in …

Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces
cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We …

Apolipoprotein E (APOE) is a component of lipoprotein particles that function in the
homeostasis of cholesterol and other lipids. Although APOE is genetically associated with …

DNA synthesis is a remarkably vulnerable phase in the cell cycle. In addition to introduction
of errors during semi-conservative replication, the inherently labile structure of the …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …

Genomic instability, the unresolved accumulation of DNA variants, is hypothesized as one of
the contributors to the natural aging process. We assessed the frequency of unresolved DNA …