Background Childhood adversity has been previously associated with alterations in brain
structure, but heterogeneous designs, methods, and measures have contributed to mixed …

Importance Adverse childhood experiences are pervasive and heterogeneous, with
potential lifelong consequences for psychiatric morbidity and brain health. Existing research …

Background Much research has focused on the deleterious neurobiological effects of
childhood adversity that may underlie internalizing disorders. Although most youth show …

Characterizing typologies of childhood adversity may inform the development of risk profiles
and corresponding interventions aimed at mitigating its lifelong consequences. A …

Discovering the processes through which early adverse experiences affect children's
nervous-system development, health, and behavior is critically important for developing …

Exposure to childhood adversity is common and associated with a host of negative
developmental outcomes. The most common approach used to examine the consequences …

Despite abundant evidence of the detrimental effects of childhood adversity, its nature and
underlying mechanisms remain contested. One influential theory, the dimensional model of …

Importance Exposure to early-life adversity alters the structural development of key brain
regions underlying neurodevelopmental impairments. The association between prenatal …

Exposure to childhood adversities (CA) is associated with subsequent alterations in regional
brain grey matter volume (GMV). Prior studies have focused mainly on severe neglect and …

An extensive literature on childhood adversity and neurodevelopment has emerged over the
past decade. We evaluate two conceptual models of adversity and neurodevelopment—the …