The coordination of proliferation and cell fate specification is of particular importance in the
developing central nervous system, because different classes of neurons are generated at …

CHX10 and VSX1 are homeodomain (HD) proteins essential for normal retinal
development. CHX10 is required first for retinal progenitor cell proliferation and later for …

Retinal progenitor cells regulate their proliferation during development so that the correct
number of each cell type is made at the appropriate time. We found that the homeodomain …

The reason why different types of vertebrate nerve cells are generated in a particular
sequence is still poorly understood. In the vertebrate retina, homeobox genes play a crucial …

Chx10 is a homeobox-containing transcription factor critical for progenitor cell proliferation
and bipolar cell determination in the developing retina. Its expression in the retina has been …

PURPOSE: To study the expression patterns of the homeobox genes Pax-6, Prox 1, and
Chx10 during chick retinal development in vivo and in vitro. METHODS: Sections of …

Recent evidence implicates homeodomain-containing proteins in the specification of cell
fates in the central nervous system. Here we report that in the embryonic mouse eye Otx2, a …

Homeobox genes are an evolutionarily conserved class of transcription factors that are
critical for development of many organ systems, including the brain and eye. During …

The paired-like homeodomain (HD) protein Chx10 is distinguished by the presence of the
CVC domain, a conserved 56 amino acid sequence C-terminal to the HD. In mammals …

The genetic linkages of the murine ocular retardation mutation with the Chx10 gene and the
murine small eye mutation with the Pax‐6 gene has demonstrated the importance of Paired …