Delineating the gene-regulatory programs underlying complex cell types is fundamental for
understanding brain function in health and disease. Here, we comprehensively examined …

Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …

Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …

Introduction Several lines of evidence point to a key role for dynamic epigenetic changes
during brain development, maturation, and learning. DNA methylation (mC) is a stable …

The mammalian brain contains diverse neuronal types, yet we lack single-cell epigenomic
assays that are able to identify and characterize them. DNA methylation is a stable …

Epigenome information in mammalian brain cells reflects their developmental history,
neuronal activity, and environmental exposures. Studying the epigenetic modifications …

Background Dynamic changes to the epigenome play a critical role in establishing and
maintaining cellular phenotype during differentiation, but little is known about the normal …

DNA methylation is a pervasive epigenetic DNA modification that strongly affects chromatin
regulation and gene expression. To date, it remains largely unknown how patterns of DNA …

Bulk-tissue DNA methylomes represent an average over many different cell types,
hampering our understanding of cell-type-specific contributions to disease development. As …

Single-cell technologies measure unique cellular signatures but are typically limited to a
single modality. Computational approaches allow the fusion of diverse single-cell data …