The search for reliable indicators of biological age, rather than chronological age, has been
ongoing for over three decades, and until recently, largely without success. Advances in the …

The aging process results in multiple traceable footprints, which can be quantified and used
to estimate an organism's age. Examples of such aging biomarkers include epigenetic …

Aging is the most important risk factor for major human lifestyle diseases, including cancer,
neurological and cardiometabolic disorders. Due to the complex interplay between genetics …

Advanced age is the main common risk factor for cancer, cardiovascular disease and
neurodegeneration. Yet, more is known about the molecular basis of any of these groups of …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

Age is the key risk factor for diseases and disabilities of the elderly. Efforts to tackle age-
related diseases and increase healthspan have suggested targeting the ageing process …

The biological markers of aging used to predict physical health status in older people are of
great interest. Telomere shortening, which occurs during the process of cell replication, was …

Biological age is not always concordant with chronological age and the departures are of
interest for understanding how diseases and environmental insults affect tissue function …

Epigenetic alterations are a hallmark of aging and age‐related diseases. Computational
models using DNA methylation data can create “epigenetic clocks” which are proposed to …

The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …