Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

By studying the loci that contribute to human longevity, we aim to identify mechanisms that
contribute to healthy aging. To identify such loci, we performed a genome‐wide association …

Over the last 30 years, a number of genetic and environmental factors that lead to decreased
length of life have been identified. Unfortunately, much less progress has been achieved in …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …

Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

Understanding the source of genetic variation in aging and using this variation to define the
molecular mechanisms of healthy aging require deep and broad quantification of a host of …

Studying the genome of centenarians may give insights into the molecular mechanisms
underlying extreme human longevity and the escape of age-related diseases. Here, we set …

In this review, we address the genetic continuum between aging and age-related diseases,
with particular attention to the ecological perspective. We describe the connections between …

A recent paper by Deelen et al.(2014) in Human Molecular Genetics reports the largest
genome-wide association study of human longevity to date. While impressive, there is a …

Studies of long-lived individuals have revealed few genetic mechanisms for protection
against age-associated disease. Therefore, we pursued genome sequencing of a related …