The mammalian HoxD cluster lies between two topologically associating domains (TADs)
matching distinct enhancer-rich regulatory landscapes. During limb development, the …

During vertebrate limb development, Hoxd genes are regulated following a bimodal strategy
involving two topologically associating domains (TADs) located on either side of the gene …

HoxA genes exhibit central roles during development and causal mutations have been
found in several human syndromes including limb malformation. Despite their importance …

The HoxD gene cluster is critical for proper limb formation in tetrapods. In the emerging limb
buds, different subgroups of Hoxd genes respond first to a proximal regulatory signal, then to …

Hox genes encode transcription factors (TFs) that establish morphological diversity in the
developing embryo. The similar DNA-binding motifs of the various HOX TFs contrast with the …

Hox genes encode transcription factors necessary for patterning the major developing
anterior to posterior embryonic axis. In addition, during vertebrate evolution, various subsets …

The combinatorial expression of Hox genes along the body axes is a major determinant of
cell fate and plays a pivotal role in generating the animal body plan. Loss of HOXA13 and …

Although promoters and their enhancers are frequently contained within a topologically
associating domain (TAD), some developmentally important genes have their promoter and …

Although Hox genes encode for conserved transcription factors (TFs), they are further
divided into anterior, central and posterior groups based on their DNA-binding domain …

Introduction During vertebrate limb development, gene members of the HoxD cluster are
transcribed in two subsequent waves, following a collinear strategy. Early on, genes located …