Human ageing is the gradual decline in organ and tissue function with increasing
chronological time, leading eventually to loss of function and death. To study the processes …

Aging is characterized by an increasing morbidity and functional decline that eventually
results in the death of an organism. Aging is the largest risk factor for numerous human …

Aging is the primary risk factor for numerous chronic, debilitating diseases. These diseases
impact quality of life of the elderly and consume a large portion of health care costs. The cost …

Abstract As 2020 is “The Year of the Rat” in the Chinese astrological calendar, it seems an
appropriate time to consider whether we should bring back the laboratory rat to front-and …

To move closer to understanding the mechanistic underpinnings of sex differences in human
longevity, we studied pet dogs to determine whether lifetime duration of ovary exposure was …

Sex differences in aging and longevity have been widely observed, with females
consistently outliving males across human populations. However, the mechanisms driving …

A robust, often underappreciated, feature of human biology is that women live longer than
men not just in technologically advanced, low-mortality countries such as those in Europe or …

Aging negatively impacts vitality and health. Many genetic pathways that regulate aging
were discovered in invertebrates. However, the genetics of aging is more complex in …

Our observation that normal human and animal cells have a limited capacity to divide and
function in vitro overturned a dogma held since the turn of the century. The dogma held that …

Males and females in many species differ in how they age and how long they live. These
differences have motivated much research, concerning both their evolution and the …