Climate change is expected to disrupt biological systems. Particularly susceptible are
species with temperature-dependent sex determination (TSD), as in many reptiles. While the …

In the year 1992, two publications on age-specific mortality rates revealed a cessation of
demographic aging at later ages in very large cohorts of two dipteran species reared under …

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Progress in gerontological research has been promoted through the use of numerous
animal models, which have helped identify possible mechanisms of aging and age-related …

Major advances in aging research have been made by studying the effect of genetic
modifications on the lifespan of organisms, such as yeast, invertebrates (worms and flies) …

Use of model organisms in aging research is problematic because our ability to extrapolate
across the tree of life is not clear. On one hand, there are conserved pathways that regulate …

Each animal species displays a specific life span, rate of aging and pattern of development
of age-dependent diseases. The genetic bases of these related features are being studied …

It is well known that women live longer than men. This gap is observed in most human
populations and can even reach 10–15 years. In addition, most of the known super …

Cultured normal human and animal cells are predestined to undergo irreversible functional
decrements that mimic age changes in the whole organism. When normal human embryonic …

External and internal stimuli cause modifications to gene and biochemical pathways. In turn,
demonstrating that biological systems continuously make short-term adaptations both to set …